As national economies around the world struggle and society realizes that wellness may be a better cost-effective way to deal with healthcare; prevention of disease will certainly become a center of attention. Aside from genetics, at the macro level, Public Health in particular, offers many new avenues for biomedical engineers. Information is key and due to our "islands of excellence", the perception we have under different crisis situations, does not allow us to reach real solutions to complex problems such as human health. Because of it I advocate for an interoperability among trans-disciplines, multi-disciplines and inter-disciplines. This approach allows us to avoid getting solutions that focus on partial knowledge of the problem and therefore getting a solution that does address all parts of an "interdependent" system. This type of complex situations cannot afford wrong decisions since it can ruin an individual's life or a nation's security, many times through irreversible damage. The information we daily receive including and related to diseases, cures, and accidents influences our perceptions. In turn these perceptions influence greatly decision making and because of those many experts that specialize in a very deep but yet narrow field, outcomes of their actions may create a bigger problem. From a worldwide perspective, everything is connected and yet disconnected. This translates into a very high cost and from a futuristic vision implies that the biggest problems society will face relate to fulfill necessities for access to clean water, food, medications and energy. A holistic systems approach is needed and proposed because of the global economy, where data mining, Knowledge Management and Geographical Information Systems are some of the emerging tools with great impact.